Prenatal diagnosis, associated findings and postnatal outcome of fetuses with truncus arteriosus communis (TAC)

Abstract Purpose To assess the spectrum of associated anomalies, intrauterine course, postnatal outcome and management fetuses with truncus arteriosus communis (TAC) Methods All cases TAC diagnosed prenatally over a period 8 years were retrospectively collected in two tertiary referral centers. additional prenatal findings assessed correlated outcome. The accuracy diagnosis was assessed. Results 39 prenatally. Mean gestational age at first 22 weeks (range, 13–38). Two lost follow-up. Correct made 21 24 (87.5%) subtype 19 (90.5%) cases. Prenatal incorrect three cases: one newborn had aortic atresia ventricular septal defect postnatally, hypoplastic right ventricle dextro Transposition Great Arteries coartation aorta third Tetralogy Fallot abnormal origin left pulmonary artery arising from ascending postnatally. These excluded further analysis. In 9 34 (26.5%) cases, an isolated finding. 13 (38.2%) chromosomal anomalies. Among them, microdeletion 22q11.2 most common prevalence 17.6% our cohort. Another 3 highly suspicious for non-chromosomal genetic syndromes due to their extra-cardiac but molecular could not be provided. Major cardiac anomalies occurred (8.8%) 20 (58.8%) respectively. Predominantly, association Additionally, severe IUGR 6 (17.6%) There 14 terminations pregnancy (41.2%), 1 (2.9%) fetal death, 5 deaths (14.7%) (41.2%) infants alive last Intention-to-treat survival rate 70%. follow-up among survivors 42 months 6–104). Postoperative health status excellent 11 (78.6%) infants, (46.2%) them needed repeated re-interventions recurrent or conduit stenosis. other (21.4%) significantly impaired non-cardiac problems. Conclusion is rare complex anomaly that can high precision. frequently leading loss perioperative mortality. Without postoperative short- medium-term excellent, independent TAC, interventions stenosis high.